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Weight Loss 

GLP1's:  Overview

Supplements & Low Dose Naltrexone

At NPS Wellness, we believe education is important. 

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Overview of GLP-1 and Its Role in Health

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GLP-1 (Glucagon-Like Peptide 1) is an incretin hormone naturally secreted by the gut. It plays a crucial role in regulating blood sugar levels, improving insulin sensitivity, and supporting overall metabolic health. GLP-1 helps maintain balanced glucose levels by performing three key functions:

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  1. Triggers Insulin Release: GLP-1 prompts the pancreas to release insulin when blood sugar levels rise, aiding in the efficient uptake of glucose into cells.

  2. Prevents Excessive Glucose Production: It prevents the liver from producing too much glucose, helping to regulate blood sugar levels between meals.

  3. Reduces Appetite and Slows Gastric Emptying: GLP-1 reduces appetite and slows the process of food leaving the stomach, promoting satiety and aiding in weight management.

GLP-1’s beneficial effects on insulin sensitivity and glucose regulation have made it a focal point in managing metabolic conditions like diabetes and obesity.

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NPS Wellness Weight Loss Membership

A weight loss membership program that incorporates semaglutide and tirzepatide offers a medically supervised approach to weight management, utilizing FDA-approved medications to help individuals achieve and maintain their weight loss goals. Both semaglutide and tirzepatide are  highly effective in supporting weight loss.

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Here’s a breakdown of each medication and the membership program:

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Semaglutide:

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Semaglutide is a GLP-1 (glucagon-like peptide-1) receptor agonist that works by mimicking a natural hormone in the body to help regulate blood sugar levels, slow gastric emptying, and reduce appetite. By decreasing hunger and promoting feelings of fullness, it helps individuals reduce calorie intake, making it easier to lose weight. Semaglutide is typically administered once a week via subcutaneous injection.

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Tirzepatide:

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Tirzepatide is a newer medication that combines the effects of GLP-1 and GIP (gastric inhibitory polypeptide) receptor agonists. This dual action enhances its effectiveness in weight loss, as it not only helps control blood sugar levels but also increases feelings of satiety, leading to reduced food intake. Tirzepatide has demonstrated even greater weight loss benefits compared to semaglutide in clinical trials and is also injected weekly.

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Weight Loss Membership:

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A weight loss membership with these medications typically includes:

  1. Personalized Treatment Plan: Upon joining, patients undergo an initial consultation to assess their health status, goals, and medical history. Based on this, a tailored treatment plan is created, which includes the appropriate medication (semaglutide or tirzepatide) and lifestyle recommendations.

  2. Ongoing Monitoring: Members receive regular check-ins with healthcare professionals to monitor their progress, adjust medication doses as needed, and ensure the program is effective. These check-ins may include blood tests, body measurements, and discussions about diet and exercise.

  3. Support and Education: Many programs offer additional support in the form of nutrition counseling, exercise plans, and behavioral health resources to encourage healthy lifestyle changes. The goal is not only to lose weight but also to maintain it long-term by making sustainable changes.

  4. Injections: Semaglutide or tirzepatide injections are typically given weekly, either at a healthcare clinic or through home delivery kits with training on how to administer the medication safely.

  5. Access to Resources: Membership programs often provide access to additional resources, such as virtual support groups, educational webinars, and other tools to help members stay motivated and on track with their weight loss journey.

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Benefits:

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  • Effective Weight Loss: Both medications have been shown to help individuals lose significant amounts of weight, often leading to better health outcomes, such as improved cholesterol levels, reduced risk of heart disease, and better blood sugar control.

  • Appetite Suppression: These medications help reduce hunger, making it easier for patients to stick to a calorie-controlled diet.

  • Convenience: With weekly injections and access to medical support, these programs offer a convenient and structured approach to weight loss.

  • Medical Supervision: Being medically supervised ensures that the treatment is safe, personalized, and adapted to each patient’s unique needs.

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The weight loss membership programs using semaglutide and tirzepatide offer an effective solution for those struggling with obesity or weight-related health conditions. However, it's important to consult with a healthcare provider to ensure that these medications are appropriate and safe for individual circumstances.

Enhancing GLP-1 Production with Probiotics and Polyphenols

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Probiotics (Lactobacillus and Bifidobacterium)

Probiotics are beneficial bacteria that support the gut microbiome, which, in turn, can enhance GLP-1 production both directly and indirectly. The right strains, in adequate quantities, are essential for achieving optimal effects. Probiotics help with digestion, reduce bloating, and contribute to fewer cravings and less hunger.

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Key Benefits of Probiotics:

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  • Improve GLP-1 Production: Lactobacillus and Bifidobacterium strains support GLP-1 secretion, helping to regulate blood sugar and appetite.

  • Gut Health: These probiotics maintain gastrointestinal homeostasis, which affects hormone secretion and supports digestive health.

  • Reduced Inflammation: They help decrease oxidative stress, inflammation, and hyperglycemia.

  • Stimulate SCFAs: Probiotics stimulate the production of short-chain fatty acids (SCFAs), such as butyrate, acetate, and propionate, which are vital for gut health.

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Probiotics play an essential role in supporting healthy digestion and overall metabolic function, contributing to better blood sugar control and fewer cravings.

Resveratrol and Its Role in GLP-1 Secretion

Resveratrol is a polyphenol with remarkable antioxidant, cardioprotective, neuroprotective, and anti-inflammatory properties. Beyond these benefits, resveratrol has also been shown to increase GLP-1 secretion, improving glucose tolerance and insulin sensitivity.

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Key Benefits of Resveratrol:

  • Increases GLP-1 Secretion: Studies suggest resveratrol activates protein kinase B (Akt) signaling, boosting insulin secretion and improving blood sugar control.

  • Supports Metabolic Health: Resveratrol enhances glucose metabolism, offering potential benefits for individuals with diabetes or metabolic syndrome.

  • Anti-inflammatory and Antioxidant: Its ability to reduce oxidative stress and inflammation supports overall health and longevity.

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Resveratrol is a powerful compound that aids in managing glucose levels and supports a healthy aging process.

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Other Polyphenols for Metabolic Health

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In addition to resveratrol, other polyphenols from plants and foods provide numerous health benefits, especially for maintaining liver function, improving energy levels, enhancing fat metabolism, and supporting cardiometabolic health. These polyphenols help increase antioxidant capacity, reduce inflammation, and promote healthy liver function, all of which are essential for weight management and metabolic efficiency.

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Recommended Orthomolecular Supplements for GLP-1 Support

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To optimize GLP-1 production and support overall metabolic health, we recommend the following Orthomolecular supplements:

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  • Hepatocore: Supports healthy liver function and enhances metabolic processes, promoting optimal detoxification and fat metabolism.

  • Hiphenolic: A powerful polyphenolic formula that aids in liver health, antioxidant activity, and metabolic efficiency, helping to manage weight and improve cardiometabolic health.

  • Ortho Biotic: A high-quality probiotic supplement featuring strains like Lactobacillus and Bifidobacterium that promote gut health and enhance GLP-1 secretion.

  • Resvoxitrol: A resveratrol-based supplement designed to support GLP-1 secretion, improve glucose tolerance, and provide antioxidant protection for overall health.

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These carefully formulated supplements help maintain metabolic balance, promote healthy weight management, and improve insulin sensitivity.

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Low Dose Naltrexone (LDN):

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Low dose naltrexone is a medication traditionally used to treat addiction at higher doses, but at much lower doses (typically 1-4.5 mg), it has gained attention for its potential benefits in weight loss and overall health.

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How it Works for Weight Loss:

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  • Appetite Regulation: LDN is thought to work by modulating the immune system and increasing endorphin production, which can lead to improved mood, reduced stress, and enhanced control over appetite.

  • Metabolism: It may help improve metabolic function by enhancing the body's natural response to insulin and reducing inflammation.

  • Fat Loss and Energy: LDN may help reduce fat accumulation and increase energy levels, leading to improved exercise performance and fat loss.

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Additional Benefits:

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  • Reduces chronic inflammation, which can be linked to obesity.

  • It is sometimes used to treat autoimmune disorders, which may indirectly support weight loss by improving overall health.

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Considerations:

 

LDN is generally well-tolerated, but side effects such as insomnia, vivid dreams, and gastrointestinal discomfort may occur. It’s often used off-label, so its long-term effects are still being studied, particularly in the context of weight loss.

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We are dedicated to helping you achieve your health and wellness goals. Contact us today to learn more about our personalized programs and start your journey towards a healthier and happier life.

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